Coexistent ARID1A-PIK3CA mutations are associated with immune-related pathways in luminal breast cancer.

ABSTRACT: Up to 40% of luminal breast cancer patients carry activating mutations in the PIK3CA gene. PIK3CA mutations commonly co-occur with other mutations, but the implication of this co-occurrence may vary according to the specific genes involved. Here, we characterized a subgroup of luminal breast cancer expressing co-mutations in ARID1A and PIK3CA genes and identified their effect on important signaling pathways. Our study included 2609 primary breast cancer samples from the TCGA and METABRIC datasets that were classified based on tumor subtype and the existence of mutations in PIK3CA and ARID1A genes. Differential expression and WGCNA analyses were performed to detect molecular modules affected by the existence of the mutations. Our results reveal various evidence for the involvement of immune

SUBMITTER: Anabel Sinberger L 

PROVIDER: S-EPMC10684499 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature