Repeated passive visual experience modulates spontaneous and non-familiar stimuli-evoked neural activity.

ABSTRACT: Familiarity creates subjective memory of repeated innocuous experiences, reduces neural and behavioral responsiveness to those experiences, and enhances novelty detection. The neural correlates of the internal model of familiarity and the cellular mechanisms of enhanced novelty detection following multi-day repeated passive experience remain elusive. Using the mouse visual cortex as a model system, we test how the repeated passive experience of a 45° orientation-grating stimulus for multiple days alters spontaneous and non-familiar stimuli evoked neural activity in neurons tuned to familiar or non-familiar stimuli. We found that familiarity elicits stimulus competition such that stimulus selectivity reduces in neurons tuned to the familiar 45° stimulus; it increases in those tuned to the 9

SUBMITTER: Niraula S 

PROVIDER: S-EPMC10684504 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature