Predictors of HbA_1c treatment response to add-on medication following metformin monotherapy: a population-based cohort study.

ABSTRACT: Evidence on the influence of patient characteristics on HbA_1c treatment response for add-on medications in patients with type 2 diabetes (T2D) is unclear. This study aims to investigate the predictors of HbA_1c treatment response for three add-on medications (sulfonylureas (SU), dipeptidyl peptidase-4 (DPP-4) and sodium-glucose cotransporter-2 (SGLT-2) inhibitor) in metformin monotherapy treated patients with T2D. This retrospective cohort study was conducted using the electronic health record data from six primary care clinics in Singapore. A total of 9748 adult patients with T2D on metformin monotherapy receiving SU, DPP-4 or SGLT-2 add-on were 1:1 propensity score matched to patients receiving other add-on medications. Patient demographics, laboratory results, diabe

SUBMITTER: Tan WY 

PROVIDER: S-EPMC10684587 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature