Maternal pre-pregnancy obesity affects the uncinate fasciculus white matter tract in preterm infants.

ABSTRACT:

Background

A growing body of evidence suggests an association between a higher maternal pre-pregnancy body mass index (BMI) and adverse long-term neurodevelopmental outcomes for their offspring. Despite recent attention to the effects of maternal obesity on fetal and neonatal brain development, changes in the brain microstructure of preterm infants born to mothers with pre-pregnancy obesity are still not well understood. This study aimed to detect the changes in the brain microstructure of obese mothers in pre-pregnancy and their offspring born as preterm infants using diffusion tensor imaging (DTI).

Methods

A total of 32 preterm infants (born to 16 mothers with normal BMI and 16 mothers with a high BMI) at <32 weeks of gestation without brain injury underwent brain magnetic

SUBMITTER: Lee JY 

PROVIDER: S-EPMC10684693 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature