Evolutionary diversity of proton and water channels on the oxidizing side of photosystem II and their relevance to function.

ABSTRACT: One of the reasons for the high efficiency and selectivity of biological catalysts arise from their ability to control the pathways of substrates and products using protein channels, and by modulating the transport in the channels using the interaction with the protein residues and the water/hydrogen-bonding network. This process is clearly demonstrated in Photosystem II (PS II), where its light-driven water oxidation reaction catalyzed by the Mn₄CaO₅ cluster occurs deep inside the protein complex and thus requires the transport of two water molecules to and four protons from the metal center to the bulk water. Based on the recent advances in structural studies of PS II from X-ray crystallography and cryo-electron microscopy, in this review we compare the channels tha

SUBMITTER: Hussein R 

PROVIDER: S-EPMC10684718 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature