Ontology highlight
ABSTRACT:
SUBMITTER: Dushianthan A
PROVIDER: S-EPMC10684757 | biostudies-literature | 2023 Nov
REPOSITORIES: biostudies-literature
Dushianthan Ahilanandan A Clark Howard W HW Brealey David D Pratt Danny D Fink James B JB Madsen Jens J Moyses Helen H Matthews Lewis L Hussell Tracy T Djukanovic Ratko R Feelisch Martin M Postle Anthony D AD Grocott Michael P W MPW
Scientific reports 20231128 1
SARS-CoV-2 directly targets alveolar epithelial cells and can lead to surfactant deficiency. Early reports suggested surfactant replacement may be effective in improving outcomes. The aim of the study to assess the feasibility and efficacy of nebulized surfactant in mechanically ventilated COVID-19 patients. Patients were randomly assigned to receive open-labelled bovine nebulized surfactant or control (ratio 3-surfactant: 2-control). This was an exploratory dose-response study starting with 108 ...[more]