Race and sex differences in the association between lifespan glycemic status and midlife cognitive function: the Bogalusa heart study.

ABSTRACT:

Introduction

Glycemic markers throughout life are associated with increased risk of midlife cognitive decline, yet it is unclear whether these associations differ by race and sex.

Methods

This study used cross-sectional analysis of prospectively maintained cohort. 1,295 participants in the Bogalusa Heart Study, a biracial epidemiological cohort located in a micropolitan area core setting, provided fasting plasma insulin (FPI) and glucose (FPG) biannually from 1973 to 2016. Memory, executive function (EF), attention, working memory (WM), and global cognition (GC), collected 2013-2016. Glycemic markers (i.e., FPG, FPI, and HOMA-IR) averaged within lifespan epochs (≤ 20 years, childhood/adolescence (C/A); 21-40 years, early adulthood (EA); and 40-58 years, midlife). Linear regr

SUBMITTER: Gwizdala KL 

PROVIDER: S-EPMC10684774 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature