Rhythmic profile of memory T and B-cells along childhood and adolescence.

ABSTRACT: Immunobiography describes the life-long effects of exogenous or endogenous stimuli on remodeling of immune cell biology, including the development of memory T and B-cells. The present study aimed at investigating the rhythms of changes in phenotypic features of memory T and B-cells along childhood and adolescence. A descriptive-observational investigation was conducted including 812 healthy volunteers, clustered into six consecutive age groups (9^Mths-1^Yr; 2^Yrs; 3-4^Yrs; 5-7^Yrs; 8-10^Yrs; 11-18^Yrs). Immunophenotypic analysis of memory T-cell (CD4⁺ and CD8⁺) and B-cell subsets were performed by flow cytometry. The results pointed out that memory-related biomarkers of T and B-cells displayed a bim

SUBMITTER: Brito-de-Sousa JP 

PROVIDER: S-EPMC10684863 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature