The associations between asthma and common comorbidities: a comprehensive Mendelian randomization study.

ABSTRACT:

Background

Asthma is a chronic respiratory disease and is often associated with multiple comorbidities. The causal relationship between asthma and these comorbidities is still unclear. This study aimed to investigate the association between genetically predicted asthma and common comorbidities.

Methods

After searching PubMed and GWAS summary statistics, we identified 26 comorbidities of asthma. The causal relationship between asthma and comorbidities was assessed in two independent GWASs by bidirectional Mendelian randomization, followed by validation of the results using a multivariate Mendelian randomization analysis and several sensitivity analyses.

Results

In the bidirectional Mendelian randomization analysis, chronic sinusitis [odds ratio (OR) = 1.54, p = 

SUBMITTER: Wang X 

PROVIDER: S-EPMC10684927 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature