Evaluation of oxidative stress in an experimental model of Crohn's disease treated with hyperbaric oxygen therapy.

ABSTRACT:

Introduction

Treatments of Inflammatory Bowel Disease (IBD) are able to control symptoms in most cases, however, a fraction of patients do not improve or have a loss of response to treatments, making it important to explore new therapeutic strategies. Hyperbaric oxygen therapy (HBO) may represent one of them. The aim of this study was to evaluate the effects of HBO therapy in an experimental model of IBD.

Methods

Sixty male BALBc mice were divided into six groups. Group 1 was colitis-induced with trinitrobenzene sulfonic acid (TNBS) + ethanol, group 2 received TNBS + ethanol plus HBO, group 3 received only ethanol, group 4 received ethanol plus HBO, group 5 received saline solution, and group 6 received saline solution plus HBO. HBO was performed for four days, subsequently,

SUBMITTER: Nakutis FS 

PROVIDER: S-EPMC10685139 | biostudies-literature | 2023 Jan-Dec

REPOSITORIES: biostudies-literature