In Silico Prediction of Selected Bioactive Compounds Present in Alpinia elegans (C.Presl) K.Schum Seed Oil as Potential Drug Candidates Against Human Cancer Cell Lines.

ABSTRACT:

Objective

Alpinia elegans (Zingiberaceae) is a Philippine endemic plant reported to have various folkloric uses. The seed oil of A. elegans has been shown to contain a majority of the following bioactive compounds: D-limonene, α-pinene, and caryophyllene oxide. The study sought to determine if the bioactive compounds found in A. elegans seed oil would be a good natural, inexpensive, and less-detrimental alternative for cancer treatment.

Methods

The study utilized in silico (Way2Drug predictive services, SwissADME, AutoDock 4) experiment to examine the aforementioned compounds as viable therapeutic candidates against human cancer cell lines.

Result

Results determined that the compounds D-limonene, α-pinene, and caryophyllene oxide were most potent against thyroid gland

SUBMITTER: Caasi JMN 

PROVIDER: S-EPMC10685237 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature