HuangQi ChiFeng decoction maintains gut microbiota and bile acid homeostasis through FXR signaling to improve atherosclerosis.

ABSTRACT: Huangqi Chifeng Decoction (HQCFT), a traditional Chinese medicine preparation, has long been used to treat cardiovascular and cerebrovascular diseases. However, the mechanism of the beneficial effect of HQCFT on atherosclerosis remains to be explored. In this work, to investigate the effects of HQCFT on bile acid (BA) metabolism and the gut microbiome in atherosclerosis, ApoE^-/- mice were fed a with high-fat diet for 16 weeks to establish the AS model. HQCFT(1.95 g kg^-1 and 3.9 g kg^-1 per day) was administered intragastrically for 8 weeks to investigate the regulatory effects of HQCFT on gut microbiota and bile acid metabolism and to inhibit the occurrence and development of AS induced by a high-fat diet. Histopathology, liver function and blood lipids were

SUBMITTER: Fu J 

PROVIDER: S-EPMC10685252 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature