Untreated cervical intraepithelial neoplasia grade 2 and subsequent risk of cervical cancer: population based cohort study.

ABSTRACT:

Objective

To describe the long term risk of cervical cancer in women with untreated (that is, undergoing active surveillance) or immediately treated cervical intraepithelial neoplasia grade 2 (CIN2).

Design

Nationwide population based historical cohort study.

Setting

Danish healthcare registries.

Participants

Women with CIN2 diagnosed in 1998-2020 and aged 18-40 years at diagnosis, who had either active surveillance or immediate treatment with large loop excision of the transformation zone (LLETZ). Women with a previous record of CIN2 or worse or LLETZ were excluded.

Main outcome measure

A Weibull survival model for interval censored time-to-event data was used to estimate the cumulative risk of cervical cancer. Inverse probability treatment weighting wa

SUBMITTER: Lycke KD 

PROVIDER: S-EPMC10685285 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature