Mendelian Randomization Analysis reveals Inverse Genetic Risks between Skin Cancers and Vitiligo.

ABSTRACT: Several observational studies have demonstrated a consistent pattern of decreased melanoma risk among patients with vitiligo. More recently, this finding has been supported by a suggested genetic relationship between the two entities, with certain variants significantly associated with an increased risk of melanoma, basal cell carcinoma, and squamous cell carcinoma but a decreased risk of vitiligo. We compared 48 associated variants from a recently published GWAS and identified three variants-located in the TYR, MC1R-DEF8, and RALY-EIF2S2-ASIP-AHCY-ITCH loci- that correlated with an increased risk for melanoma, basal cell carcinoma, and squamous cell carcinoma and a decreased risk for vitiligo. We then used results of skin cancers and vitiligo GWAS to com

SUBMITTER: Rashid S 

PROVIDER: S-EPMC10685305 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature