Cobalt-Catalyzed Efficient Asymmetric Hydrogenation of α-Primary Amino Ketones.

ABSTRACT: Based on an amino-group-assisted coordination strategy and a proton-shuttle-activated outer-sphere mode, the cobalt-catalyzed asymmetric hydrogenation of α-primary amino ketones has been developed, resulting in the efficient synthesis of chiral vicinal amino alcohols bearing functionalized aryl rings in high yields and enantioselectivities (up to 99% enantiomeric excess (ee)) within 0.5 h.

SUBMITTER: Yang H 

PROVIDER: S-EPMC10685343 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature