A proteomic analysis of atrial fibrillation in a prospective longitudinal cohort (AGES-Reykjavik study).

ABSTRACT:

Aims

Atrial fibrillation (AF) is associated with high risk of comorbidities and mortality. Our aim was to examine causal and predictive relationships between 4137 serum proteins and incident AF in the prospective population-based Age, Gene/Environment Susceptibility-Reykjavik (AGES-Reykjavik) study.

Methods and results

The study included 4765 participants, of whom 1172 developed AF. Cox proportional hazards regression models were fitted for 4137 baseline protein measurements adjusting for known risk factors. Protein associations were tested for replication in the Cardiovascular Health Study (CHS). Causal relationships were examined in a bidirectional, two-sample Mendelian randomization analysis. The time-dependent area under the receiver operating characteristic curve (AUC)-

SUBMITTER: Jonmundsson T 

PROVIDER: S-EPMC10685397 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature