Short, Scalable Access to Pyrrovobasine.

ABSTRACT: A concise gram-scale synthesis of pyrrovobasine (1) is reported. Key transformations include a three-step decagram-scale synthesis of the tetracyclic compound, Mn-mediated direct radical cyclization, and the introduction of a naturally rare pyrraline structure. The synthesis is designed to be applicable to gram-scale synthesis using inexpensive and readily available reagents.

SUBMITTER: Yu L 

PROVIDER: S-EPMC10685420 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature