Relationship between serum interleukin-6 levels and severity of coronary artery disease undergoing percutaneous coronary intervention.

ABSTRACT:

Background

Cytokines play a potential role in atherosclerosis pathogenesis and progression. We investigated the association of interleukin-6 (IL-6) with the angiographic severity of coronary artery disease (CAD).

Methods

Three hundred ten angiografically diagnosed CAD patients and 210 controls were enrolled in this study. CAD patients were stratified according to IL-6 cut-off value into high levels IL-6 group (≥ 9.5 pg/mL) and low levels IL-6 group (< 9.5 pg/mL). The severity of CAD was assessed according to Gensini score (GS), artery stenosis degree and the number of vessels involved. The mean age was 60.3 ± 11.0 years.

Results

The level of IL-6 in patients was increased compared to controls and ranged from 1.5 to 3640.0 pg/mL. High levels of IL-6 were significantly

SUBMITTER: Bouzidi N 

PROVIDER: S-EPMC10685463 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature