Identification of hypervirulent Klebsiella pneumoniae based on biomarkers and Galleria mellonella infection model.

ABSTRACT:

Background

Currently, clinical laboratories lack an effective method to differentiate between classical Klebsiella pneumoniae (cKP) and hypervirulent Klebsiella pneumoniae (hvKP) strains, leading to delays in diagnosing and treating hvKP infections. Previous studies have identified peg-344, iroB, iucA, _prmpA, _prmpA2, and siderophores (SP) yields greater than 30 μg/ml as reliable markers for distinguishing hvKP from cKp strains. However, these diagnostic tests were conducted on a relatively small study population and lacked sufficient clinical data support. In this study, hvKP strains were identified by biomarker analysis and the Galleria mellonella model. Combined with in vitro and in vivo experiments, the reliability of clinical identification method of hvKP

SUBMITTER: Mai D 

PROVIDER: S-EPMC10685466 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature