MiR-590-5p/Tiam1-mediated glucose metabolism promotes malignant evolution of pancreatic cancer by regulating SLC2A3 stability.

ABSTRACT:

Background

T lymphoma invasion and metastasis 1 (Tiam1) is a tumor related gene that specifically activates Rho-like GTPases Rac1 and plays a critical role in the progression of various malignancies. Glycolysis plays an important role in cancer progression, it is crucial for supplying energy and producing metabolic end products, which can maintain the survival of tumor cells. As yet, however, the mechanism of Tiam1 in glycolysis reprogramming of pancreatic cancer (PC) remains to be clarified. Here, we investigated the functional role of Tiam1 in PC cell proliferation, metastasis and glycolysis reprogramming. It is expected to provide a new direction for clinical treatment.

Methods

The clinical relevance of Tiam1 was evaluated in 66 patients with PC, the effect of Tiam1 on ce

SUBMITTER: Liu Y 

PROVIDER: S-EPMC10685474 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature