Prevention of STAT3-related pathway in SK-N-SH cells by natural product astaxanthin.

ABSTRACT:

Purpose

Neuroblastoma (NB) is the most common solid malignancy in children. Despite current intensive treatment, the long-term event-free survival rate is less than 50% in these patients. Thus, patients with NB urgently need more valid treatment strategies. Previous research has shown that STAT3 may be an effective target in high-risk NB patients. However, there are no effective inhibitors in clinical evaluation with low toxicity and few side effects. Astaxanthin is a safe and natural anticancer product. In this study, we investigated whether astaxanthin could exert antitumor effects in the SK-N-SH neuroblastoma cancer cell line.

Method

MTT and colony formation assays were used to determine the effect of astaxanthin on the proliferation and colony formation of SK-N-SH cells.

SUBMITTER: Sun SQ 

PROVIDER: S-EPMC10685499 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature