Myocardial protection with phosphocreatine in high-risk cardiac surgery patients: a randomized trial.

ABSTRACT:

Background

This study was conducted to test the hypothesis that phosphocreatine (PCr), administered intravenously and as cardioplegia adjuvant in patients undergoing cardiac surgery with prolonged aortic cross clamping and cardiopulmonary bypass (CPB) time, would decrease troponin I concentration after surgery.

Methods

In this randomized, double-blind, placebo-controlled pilot study we included 120 patients undergoing double/triple valve repair/replacement under cardiopulmonary bypass in the cardiac surgery department of a tertiary hospital. The treatment group received: intravenous administration of 2 g of PCr after anesthesia induction; 2.5 g of PCr in every 1 L of cardioplegic solution (concentration = 10 mmol/L); intravenous administration of 2 g of PCr immediately after

SUBMITTER: Lomivorotov V 

PROVIDER: S-EPMC10685505 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature