The CAR macrophage cells, a novel generation of chimeric antigen-based approach against solid tumors.

ABSTRACT: Today, adoptive cell therapy has many successes in cancer therapy, and this subject is brilliant in using chimeric antigen receptor T cells. The CAR T cell therapy, with its FDA-approved drugs, could treat several types of hematological malignancies and thus be very attractive for treating solid cancer. Unfortunately, the CAR T cell cannot be very functional in solid cancers due to its unique features. This treatment method has several harmful adverse effects that limit their applications, so novel treatments must use new cells like NK cells, NKT cells, and macrophage cells. Among these cells, the CAR macrophage cells, due to their brilliant innate features, are more attractive for solid tumor therapy and seem to be a better candidate for the prior treatment methods. The CAR macrophage cel

SUBMITTER: Hadiloo K 

PROVIDER: S-EPMC10685521 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature