Quality assurance in a phase III, multicenter, randomized trial of POstmastectomy radioThErapy in Node posiTive breast cancer with or without Internal mAmmary nodaL irradiation (POTENTIAL): a planning benchmark case.

ABSTRACT:

Purpose

To report the planning benchmark case results of the POTENTIAL trial-a multicenter, randomized, phase 3 trial-to evaluate the value of internal mammary nodal (IMN) irradiation for patients with high-risk breast cancer.

Methods

All participating institutions were provided the outlines of one benchmark case, and they generated radiation therapy plans per protocol. The plans were evaluated by a quality assurance team, after which the institutions resubmitted their revised plans. The information on beams arrangement, skin flash, inhomogeneity corrections, and protocol compliance was assessed in the first and final submission.

Results

The plans from 26 institutions were analyzed. Some major deviations were found in the first submission. The protocol compliance rate

SUBMITTER: Song YC 

PROVIDER: S-EPMC10685528 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature