A novel necroptosis signature for predicting survival in lung adenocarcinoma.

ABSTRACT:

Background

To explore the necroptosis-related genes (NRGs) signature and its predictive values in lung adenocarcinoma (LUAD).

Methods

The training cohort consisted of tumor samples from The Cancer Genome Atlas, and the validation set comprised data from the Gene Expression Omnibus. Univariate and multivariate Cox regression analyses were applied to identify the prognostic NRG signature as an independent molecular indicator. Correlation analysis was used for the association assessment between the NRG signature and immune checkpoint molecules.

Results

NRGs involved in necroptosis and immune NOD-like receptor signaling. The NRG signature based on eight NRGs can divide tumors into high-risk and low-risk groups, which was significantly associated with worse survival. Multi

SUBMITTER: Zang K 

PROVIDER: S-EPMC10685572 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature