Dataset Information

Metagenomic analysis reveals distinct changes in the gut microbiome of obese Chinese children.

ABSTRACT:

Background

The prevalence of obese children in China is increasing, which poses a great challenge to public health. Gut microbes play an important role in human gut health, and changes in gut status are closely related to obesity. However, how gut microbes contribute to obesity in children remains unclear. In our study, we performed shotgun metagenomic sequencing of feces from 23 obese children, 8 overweight children and 22 control children in Chengdu, Sichuan, China.

Results

We observed a distinct difference in the gut microbiome of obese children and that of controls. Compared with the controls, bacterial pathogen Campylobacter rectus was significantly more abundant in obese children. In addition, functional annotation of microbial genes revealed that there might be gut inflammation in obese children. The guts of overweight children might belong to the transition state between obese and control children due to a gradient in relative abundance of differentially abundant species. Finally, we compared the gut metagenomes of obese Chinese children and obese Mexican children and found that Trichuris trichiura was significantly more abundant in the guts of obese Mexican children.

Conclusions

Our results contribute to understanding the changes in the species and function of intestinal microbes in obese Chinese children.

SUBMITTER: Li P

PROVIDER: S-EPMC10685578 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature

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Publications

Metagenomic analysis reveals distinct changes in the gut microbiome of obese Chinese children.

Li Ping P Jiang Jiyang J Li Yifei Y Lan Yue Y Yang Fan F Wang Jiao J Xie Yuxin Y Xiong Fei F Wu Jinhui J Liu Hanmin H Fan Zhenxin Z

BMC genomics 20231129 1

<h4>Background</h4>The prevalence of obese children in China is increasing, which poses a great challenge to public health. Gut microbes play an important role in human gut health, and changes in gut status are closely related to obesity. However, how gut microbes contribute to obesity in children remains unclear. In our study, we performed shotgun metagenomic sequencing of feces from 23 obese children, 8 overweight children and 22 control children in Chengdu, Sichuan, China.<h4>Results</h4>We o ...[more]

PMID: 38031016

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Dataset Information

Metagenomic analysis reveals distinct changes in the gut microbiome of obese Chinese children.

Background

Results

Conclusions

Publications

Metagenomic analysis reveals distinct changes in the gut microbiome of obese Chinese children.

Similar Datasets

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