Metagenomic analysis reveals distinct changes in the gut microbiome of obese Chinese children.

ABSTRACT:

Background

The prevalence of obese children in China is increasing, which poses a great challenge to public health. Gut microbes play an important role in human gut health, and changes in gut status are closely related to obesity. However, how gut microbes contribute to obesity in children remains unclear. In our study, we performed shotgun metagenomic sequencing of feces from 23 obese children, 8 overweight children and 22 control children in Chengdu, Sichuan, China.

Results

We observed a distinct difference in the gut microbiome of obese children and that of controls. Compared with the controls, bacterial pathogen Campylobacter rectus was significantly more abundant in obese children. In addition, functional annotation of microbial genes revealed that there might be gut in

SUBMITTER: Li P 

PROVIDER: S-EPMC10685578 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature