Identification of genetic associations and functional SNPs of bovine KLF6 gene on milk production traits in Chinese holstein.

ABSTRACT:

Background

Our previous research identified the Kruppel like factor 6 (KLF6) gene as a prospective candidate for milk production traits in dairy cattle. The expression of KLF6 in the livers of Holstein cows during the peak of lactation was significantly higher than that during the dry and early lactation periods. Notably, it plays an essential role in activating peroxisome proliferator-activated receptor α (PPARα) signaling pathways. The primary aim of this study was to further substantiate whether the KLF6 gene has significant genetic effects on milk traits in dairy cattle.

Results

Through direct sequencing of PCR products with pooled DNA, we totally identified 12 single nucleotide polymorphisms (SNPs) within the KLF6 gene. The set of SNPs encompasses 7 located in 5' flanki

SUBMITTER: Liu Y 

PROVIDER: S-EPMC10685595 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature