Wireless microelectrode arrays for selective and chronically stable peripheral nerve stimulation for hindlimb movement.

ABSTRACT: Objective. Maximizing the stability of implanted neural interfaces will be critical to developing effective treatments for neurological and neuromuscular disorders. Our research aims to develop a stable neural interface using wireless communication and intrafascicular microelectrodes to provide highly selective stimulation of neural tissue.Approach. We implanted a wireless floating microelectrode array into the left sciatic nerve of six rats. Over a 38 week implantation period, we recorded stimulation thresholds and movements evoked at each implanted electrode. We also tracked each animal's response to sensory stimuli and performance on two different walking tasks.Main results. Presence of the microelectrode array inside the sciatic nerve did not cause any obvious moto

SUBMITTER: Frederick RA 

PROVIDER: S-EPMC10685740 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature