Patent Ductus Arteriosus and Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension: A Bayesian Meta-Analysis.

ABSTRACT:

Importance

Bronchopulmonary dysplasia (BPD) is often associated with pulmonary vascular disease and secondary pulmonary hypertension (PH). The pathogenesis of BPD-associated PH (BPD-PH) is complex and involves prenatal and postnatal factors that disrupt pulmonary vascular development, and patent ductus arteriosus (PDA) is a factor potentially associated with risk of BPD-PH that has been identified in very recent studies.

Objective

To explore the association of PDA with BPD-PH using a bayesian model-averaged (BMA) meta-analysis of studies.

Data sources

PubMed and Embase were searched up to April 2023. Key search terms included BPD and PH.

Study selection

Studies examining infants with gestational age 32 weeks or less and reporting data on PDA and risk of BPD-PH.

SUBMITTER: Villamor E 

PROVIDER: S-EPMC10685885 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature