Rapid discovery of terpene tailoring enzymes for total biosynthesis.

ABSTRACT: Twenty oxygenated aristolochene congeners were rapidly synthesised by combining genes from four different fungal pathways in the fungal host organism Aspergillus oryzae. Compounds produced in a single step include the natural product hypoxylan A and an epimer of guignaderemophilane C. A new fungal aromatase was discovered that produces phenols by oxidative demethylation.

SUBMITTER: Sun Y 

PROVIDER: S-EPMC10686045 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature