Combining multi-omics analysis to identify host-targeted targets for the control of Brucella infection.

ABSTRACT: Human infections caused by Brucella (called brucellosis) are among the most common zoonoses worldwide with an estimated 500,000 cases each year. Since chronic Brucella infections are extremely difficult to treat, there is an urgent need for more effective therapeutics. As a facultative intracellular bacterium, Brucella is strictly parasitic in the host cell. Here, we performed proteomic and transcriptomic and metabolomic analyses on Brucella infected patients, mice and cells that provided an extensive "map" of physiological changes in brucellosis patients and characterized the metabolic pathways essential to the response to infection, as well as the associated cellular response and molecular mechanisms. This is the first report utilizing multi-omics analysis to investigate the global respo

SUBMITTER: Yu J 

PROVIDER: S-EPMC10686141 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature