Assessment of the Degree of Variation of Histologic Inflammation in Ulcerative Colitis.

ABSTRACT:

Introduction

Treatment of ulcerative colitis (UC) now includes mucosal healing. Adoption of histologic end points is hindered by a lack of evidence guiding optimal sampling, interpretation, and reproducibility of results.

Methods

We analyzed biopsy fragments from colonoscopies in 92 patients with UC. Fragments were scored using 6-point histologic inflammatory activity (HIA) scale. Variability was determined using ordinal representations of HIA scores. The most frequently observed score and percentage of biopsy fragments with that score were determined for each biopsy, each segment, and across all 3 segments for each colonoscopy. Mean percentages and 95% confidence intervals (CIs) were calculated.

Results

We reviewed 1802 biopsy fragments. The mean percentages of intra

SUBMITTER: Mikolajczyk AE 

PROVIDER: S-EPMC10686247 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature