Designing Collagen-Binding Peptide with Enhanced Properties Using Hydropathic Free Energy Predictions.

ABSTRACT: Collagen is fundamental to a vast diversity of health functions and potential therapeutics. Short peptides targeting collagen are attractive for designing modular systems for site-specific delivery of bioactive agents. Characterization of peptide-protein binding involves a larger number of potential interactions that require screening methods to target physiological conditions. We build a hydropathy-based free energy estimation tool which allows quick evaluation of peptides binding to collagen. Previous studies showed that pH plays a significant role in collagen structure and stability. Our design tool enables probing peptides for their collagen-binding property across multiple pH conditions. We explored binding features of currently known collagen-binding peptides, collagen type I alpha c

SUBMITTER: Boone K 

PROVIDER: S-EPMC10686322 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature