Psychosis Endophenotypes: A Gene-Set-Specific Polygenic Risk Score Analysis.

ABSTRACT:

Background and hypothesis

Endophenotypes can help to bridge the gap between psychosis and its genetic predispositions, but their underlying mechanisms remain largely unknown. This study aims to identify biological mechanisms that are relevant to the endophenotypes for psychosis, by partitioning polygenic risk scores into specific gene sets and testing their associations with endophenotypes.

Study design

We computed polygenic risk scores for schizophrenia and bipolar disorder restricted to brain-related gene sets retrieved from public databases and previous publications. Three hundred and seventy-eight gene-set-specific polygenic risk scores were generated for 4506 participants. Seven endophenotypes were also measured in the sample. Linear mixed-effects models were fitted to

SUBMITTER: Wang B 

PROVIDER: S-EPMC10686343 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature