Quantitative response of macular neovascularisation to loading phase of aflibercept in neovascular age-related macular degeneration.

ABSTRACT:

Purpose

To evaluate quantitative morphological changes in macular neovascularisation (MNV) network after aflibercept therapy in neovascular age-related macular degeneration (nAMD) patients.

Methods

Consecutive treatment-naïve patients with optical coherence tomography (OCT) angiography confirmed MNV due to nAMD who completed a loading phase of intravitreal aflibercept injections. A quantitative analysis of the vascular network remodelling was performed using a computational software (Angiotool).

Results

A total of 53 eyes of 52 patients were included in the analysis. The total MNV area decreased significantly after three aflibercept injections (p = 0.003). Total vessel area and vessel density decreased respectively of 20% and 12% at V3 (p < 0.001 in both cases). Other

SUBMITTER: Montesel A 

PROVIDER: S-EPMC10686403 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature