Loss of Aspm causes increased apoptosis of developing neural cells during mouse cerebral corticogenesis.

ABSTRACT: Abnormal spindle-like microcephaly associated (ASPM) is a causative gene of primary autosomal recessive microcephaly. Microcephaly is considered to be a consequence of a small brain, but the associated molecular mechanisms are not fully understood. In this study, we generated brain-specific Aspm knockout mice to evaluate the fetal brain phenotype and observed cortical reduction in the late stage of murine cortical development. It has been reported that the total number of neurons is regulated by the number of neural stem and progenitor cells. In the Aspm knockout mice, no apparent change was shown in the neural progenitor cell proliferation and there was no obvious effect on the number of newly generated neurons in the developing cortex. On the other hand, the knockout mice showed a consta

SUBMITTER: Tonosaki M 

PROVIDER: S-EPMC10686469 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature