MiRNA cargo in circulating vesicles from neurons is altered in individuals with schizophrenia and associated with severe disease.

ABSTRACT: While RNA expression appears to be altered in several brain disorders, the constraints of postmortem analysis make it impractical for well-powered population studies and biomarker development. Given that the unique molecular composition of neurons are reflected in their extracellular vesicles (EVs), we hypothesized that the fractionation of neuron derived EVs provides an opportunity to specifically profile their encapsulated contents noninvasively from blood. To investigate this hypothesis, we determined miRNA expression in microtubule associated protein 1B (MAP1B)-enriched serum EVs derived from neurons from a large cohort of individuals with schizophrenia and nonpsychiatric comparison participants. We observed dysregulation of miRNA in schizophrenia subjects, in particular those with tre

SUBMITTER: Barnett MM 

PROVIDER: S-EPMC10686555 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature