Feline papillomavirus-associated Merkel cell carcinoma: a comparative review with human Merkel cell carcinoma.

ABSTRACT: Merkel cell carcinoma (MCC) is a rare skin tumor that shares a similar immunophenotype with Merkel cells, although its origin is debatable. More than 80% of human MCC cases are associated with Merkel cell polyomavirus infections and viral gene integration. Recent studies have shown that the clinical and pathological characteristics of feline MCC are comparable to those of human MCC, including its occurrence in aged individuals, aggressive behavior, histopathological findings, and the expression of Merkel cell markers. More than 90% of feline MCC are positive for the Felis catus papillomavirus type 2 (FcaPV2) gene. Molecular changes involved in papillomavirus-associated tumorigenesis, such as increased p16 and decreased retinoblastoma (Rb) and p53 protein levels, were observed in FcaPV2-pos

SUBMITTER: Chambers JK 

PROVIDER: S-EPMC10686778 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature