NF-κB downstream miR-1262 disturbs colon cancer cell malignant behaviors by targeting FGFR1.

ABSTRACT: Despite substantial advancements in screening, surgery, and chemotherapy, colorectal cancer remains the second most lethal form of the disease. Nuclear factor kappa B (NF-κB) signaling is a critical driver facilitating the malignant transformation of chronic inflammatory bowel diseases. In this study, deregulated miRNAs that could play a role in colon cancer are analyzed and investigated for specific functions in vitro using cancer cells and in vivo using a subcutaneous xenograft model. miRNA downstream targets are analyzed, and predicted binding and regulation are verified. miR-1262, an antitumor miRNA, is downregulated in colon cancer tissue samples and cell lines. miR-1262 overexpression suppresses colon cancer malignant behaviors in vitro and tumor development and

SUBMITTER: Zhang W 

PROVIDER: S-EPMC10686795 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature