Trans-vaccenic acid reprograms CD8⁺ T cells and anti-tumour immunity.

ABSTRACT: Diet-derived nutrients are inextricably linked to human physiology by providing energy and biosynthetic building blocks and by functioning as regulatory molecules. However, the mechanisms by which circulating nutrients in the human body influence specific physiological processes remain largely unknown. Here we use a blood nutrient compound library-based screening approach to demonstrate that dietary trans-vaccenic acid (TVA) directly promotes effector CD8⁺ T cell function and anti-tumour immunity in vivo. TVA is the predominant form of trans-fatty acids enriched in human milk, but the human body cannot produce TVA endogenously¹. Circulating TVA in humans is mainly from ruminant-derived foods including beef, lamb and dairy products such as milk and butter^2,3

SUBMITTER: Fan H 

PROVIDER: S-EPMC10686835 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature