Antimicrobial susceptibility of Treponema pallidum subspecies pallidum: an in-vitro study.

ABSTRACT:

Background

The increasing incidence of syphilis and the limitations of first-line treatment with penicillin, particularly in neurosyphilis, neonatal syphilis, and pregnancy, highlight the need to expand the therapeutic repertoire for effective management of this disease. We assessed the in-vitro efficacy of 18 antibiotics from several classes on Treponema pallidum subspecies pallidum (T pallidum), the syphilis bacteria.

Methods

Using the in-vitro culture system for T pallidum, we exposed the pathogen to a concentration range of each tested antibiotic. After a 7-day incubation, the treponemal burden was evaluated by quantitative PCR targeting the T pallidum tp0574 gene. The primary outcome was the minimum inhibitory concentration (MIC) at which the quantitative PCR values wer

SUBMITTER: Tantalo LC 

PROVIDER: S-EPMC10686905 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature