Chemical constituents from the medicinal herb-derived fungus Chaetomium globosum Km1226.

ABSTRACT:

Background

Endophytic fungi have proven to be a rich source of novel natural products with a wide-array of biological activities and higher levels of structural diversity.

Results

Chemical investigation on the liquid- and solid-state fermented products of Chaetomium globosum Km1226 isolated from the littoral medicinal herb Atriplex maximowicziana Makino resulted in the isolation of compounds 1-14. Their structures were determined by spectroscopic analysis as three previously undescribed C₁₃-polyketides, namely aureonitol C (1), mollipilins G (2), and H (3), along with eleven known compounds 4-14. Among these, mollipilin A (5) exhibited significant nitric oxide production inhibitory activity in LPS-induced BV-2 microglial cells with an IC₅₀ value of 0.7 

SUBMITTER: Chang CH 

PROVIDER: S-EPMC10686906 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature