Using trials of caloric restriction and bariatric surgery to explore the effects of body mass index on the circulating proteome.

ABSTRACT: Thousands of proteins circulate in the bloodstream; identifying those which associate with weight and intervention-induced weight loss may help explain mechanisms of diseases associated with adiposity. We aimed to identify consistent protein signatures of weight loss across independent studies capturing changes in body mass index (BMI). We analysed proteomic data from studies implementing caloric restriction (Diabetes Remission Clinical trial) and bariatric surgery (By-Band-Sleeve), using SomaLogic and Olink Explore1536 technologies, respectively. Linear mixed models were used to estimate the effect of the interventions on circulating proteins. Twenty-three proteins were altered in a consistent direction after both bariatric surgery and caloric restriction, suggesting that these proteins a

SUBMITTER: Goudswaard LJ 

PROVIDER: S-EPMC10686974 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature