PD-1^- CD45RA⁺ effector-memory CD8 T cells and CXCL10⁺ macrophages are associated with response to atezolizumab plus bevacizumab in advanced hepatocellular carcinoma.

ABSTRACT: The combination of atezolizumab plus bevacizumab (atezo/bev) has dramatically changed the treatment landscape of advanced HCC (aHCC), achieving durable responses in some patients. Using single-cell transcriptomics, we characterize the intra-tumoural and peripheral immune context of patients with aHCC treated with atezo/bev. Tumours from patients with durable responses are enriched for PDL1⁺ CXCL10⁺ macrophages and, based on cell-cell interaction analysis, express high levels of CXCL9/10/11 and are predicted to attract peripheral CXCR3⁺ CD8⁺ effector-memory T cells (CD8 T_EM) into the tumour. Based on T cell receptor sharing and pseudotime trajectory analysis, we propose that CD8 T_EM preferentially differentiate into clonally-

SUBMITTER: Cappuyns S 

PROVIDER: S-EPMC10687033 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature