Ontology highlight
ABSTRACT:
SUBMITTER: Chen B
PROVIDER: S-EPMC10687070 | biostudies-literature | 2023 Nov
REPOSITORIES: biostudies-literature
Nature communications 20231129 1
The dominant mutational signature in colorectal cancer genomes is C > T deamination (COSMIC Signature 1) and, in a small subgroup, mismatch repair signature (COSMIC signatures 6 and 44). Mutations in common colorectal cancer driver genes are often not consistent with those signatures. Here we perform whole-genome sequencing of normal colon crypts from cancer patients, matched to a previous multi-omic tumour dataset. We analyse normal crypts that were distant vs adjacent to the cancer. In contras ...[more]