6-Pyrazolylpurine and its deaza derivatives as nucleobases for silver(I)-mediated base pairing with pyrimidines.

ABSTRACT: The artificial nucleobase 6-pyrazolylpurine (6PP) and its deaza derivatives 1-deaza-6-pyrazolylpurine (^1D6PP), 7-deaza-6-pyrazolylpurine (^7D6PP), and 1,7-dideaza-6-pyrazolylpurine (^1,7D6PP) were investigated with respect to their ability to differentiate between the canonical nucleobases cytosine and thymine by means of silver(I)-mediated base pairing. As shown by temperature-dependent UV spectroscopy and by circular dichroism spectroscopy, 6PP and (to a lesser extent) ^7D6PP form stable silver(I)-mediated base pairs with cytosine, but not with thymine. ^1D6PP and ^1,7D6PP do not engage in the formation of stabilizing silver(I)-mediated base pairs with cytosine or thymine. The different behavior of ^1D6PP, ^7D

SUBMITTER: Escher D 

PROVIDER: S-EPMC10687122 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature