Arachidonate 15-lipoxygenase-mediated production of Resolvin D5_{n-3 DPA} abrogates pancreatic stellate cell-induced cancer cell invasion.

ABSTRACT: Activation of pancreatic stellate cells (PSCs) to cancer-associated fibroblasts (CAFs) is responsible for the extensive desmoplastic reaction observed in PDAC stroma: a key driver of pancreatic ductal adenocarcinoma (PDAC) chemoresistance leading to poor prognosis. Specialized pro-resolving mediators (SPMs) are prime modulators of inflammation and its resolution, traditionally thought to be produced by immune cells. Using liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based lipid mediator profiling PSCs as well as primary human CAFs express enzymes and receptors to produce and respond to SPMs. Human PSC/CAF SPM secretion profile can be modulated by rendering these cells activated [transforming growth factor beta (TGF-β)] or quiescent [all-trans retinoic acid (ATRA)]. ATRA

SUBMITTER: Aguirre GA 

PROVIDER: S-EPMC10687150 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature