Gut microbiome dysbiosis in men who have sex with men increases HIV infection risk through immunity homeostasis alteration.

ABSTRACT:

Objectives

Recent studies pointed out that gut microbiome dysbiosis in HIV infection was possibly confounded in men who have sex with men (MSM), but there is a lack of evidence. It also remained unclear how MSM-associated gut microbiome dysbiosis affected human health. This study aimed to compare the differences in gut microbiome changes between HIV and MSM and reveal the potential impacts of MSM-associated gut microbiome dysbiosis on the immune system.

Methods

We searched available studies based on the PubMed database, and all gut microbiome changes associated with HIV infection and MSM were extracted from the enrolled studies. The gutMgene database was used to identify the target genes and metabolites of the gut microbiome. Bioinformatic technology and single-cell RNA sequ

SUBMITTER: Li K 

PROVIDER: S-EPMC10687210 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature