An untapped window of opportunity for glioma: targeting therapy-induced senescence prior to recurrence.

ABSTRACT: High-grade gliomas are primary brain tumors that are incredibly refractory long-term to surgery and chemoradiation, with no proven durable salvage therapies for patients that have failed conventional treatments. Post-treatment, the latent glioma and its microenvironment are characterized by a senescent-like state of mitotic arrest and a senescence-associated secretory phenotype (SASP) induced by prior chemoradiation. Although senescence was once thought to be irreversible, recent evidence has demonstrated that cells may escape this state and re-enter the cell cycle, contributing to tumor recurrence. Moreover, senescent tumor cells could spur the growth of their non-senescent counterparts, thereby accelerating recurrence. In this review, we highlight emerging evidence supporting the use of

SUBMITTER: Riviere-Cazaux C 

PROVIDER: S-EPMC10687268 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature