Effective sequential combined therapy with carboplatin and a CDC7 inhibitor in ovarian cancer.

ABSTRACT:

Background

The enhancement of DNA damage repair is one of the important mechanisms of platinum resistance. Protein cell division cycle 7 (CDC7) is a conserved serine/threonine kinase that plays important roles in the initiation of DNA replication and is associated with chemotherapy resistance in ovarian cancer. However, whether the CDC7 inhibitor XL413 has antitumor activity against ovarian cancer and its relationship with chemosensitivity remain poorly elucidated.

Methods

We evaluated the antitumor effects of carboplatin combined with XL413 for ovarian cancer in vitro and in vivo. Cell viability inhibition, colony formation and apoptosis were assessed. The molecules related to DNA repair and damage were investigated. The antitumor effects of carboplatin combined with XL413

SUBMITTER: Li J 

PROVIDER: S-EPMC10687335 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature